A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
Identifieur interne : 001923 ( Main/Exploration ); précédent : 001922; suivant : 001924A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
Auteurs : Vineet D. Menachery ; Boyd L. Yount ; Kari Debbink ; Sudhakar Agnihothram ; Lisa E. Gralinski ; Jessica A. Plante ; Rachel L. Graham ; Trevor Scobey ; Xing-Yi Ge [République populaire de Chine] ; Eric F. Donaldson ; Scott H. Randell ; Antonio Lanzavecchia [Suisse] ; Wayne A. Marasco ; Zhengli-Li Shi [République populaire de Chine] ; Ralph S. BaricSource :
- Nature Medicine [ 1078-8956 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps monoclonaux (immunologie), Cellules épithéliales (anatomopathologie), Cellules épithéliales (virologie), Chiroptera (virologie), Femelle, Humains, Lignée cellulaire, Phylogénie, Poumon (virologie), Réplication virale, Souris de lignée BALB C, Syndrome respiratoire aigu sévère (virologie), Tests de neutralisation, Virulence, Virus du SRAS (immunologie), Virus du SRAS (pathogénicité), Virus du SRAS (physiologie), Épidémies.
- MESH :
- anatomopathologie : Cellules épithéliales.
- immunologie : Anticorps antiviraux, Anticorps monoclonaux, Virus du SRAS.
- pathogénicité : Virus du SRAS.
- physiologie : Virus du SRAS.
- virologie : Cellules épithéliales, Chiroptera, Poumon, Syndrome respiratoire aigu sévère.
- Animaux, Femelle, Humains, Lignée cellulaire, Phylogénie, Réplication virale, Souris de lignée BALB C, Tests de neutralisation, Virulence, Épidémies.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (immunology), Antibodies, Viral (immunology), Cell Line, Chiroptera (virology), Epidemics, Epithelial Cells (pathology), Epithelial Cells (virology), Female, Humans, Lung (virology), Mice, Inbred BALB C, Neutralization Tests, Phylogeny, SARS Virus (immunology), SARS Virus (pathogenicity), SARS Virus (physiology), Severe Acute Respiratory Syndrome (virology), Virulence, Virus Replication.
- MESH :
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Viral.
- immunology : SARS Virus.
- pathogenicity : SARS Virus.
- pathology : Epithelial Cells.
- physiology : SARS Virus.
- virology : Chiroptera, Epithelial Cells, Lung, Severe Acute Respiratory Syndrome.
- Animals, Cell Line, Epidemics, Female, Humans, Mice, Inbred BALB C, Neutralization Tests, Phylogeny, Virulence, Virus Replication.
Abstract
Ralph Baric, Vineet Menachery and colleagues characterize a SARS-like coronavirus circulating in Chinese horseshoe bats to determine its potential to infect primary human airway epithelial cells, cause disease in mice and respond to available therapeutics.
The online version of this article (doi:10.1038/nm.3985) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1038/nm.3985
PubMed: 26552008
PubMed Central: 4797993
Affiliations:
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Le document en format XML
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Donaldson</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.10698.36</institution-id><institution-id institution-id-type="ISNI">0000000122483208</institution-id><institution>Department of Epidemiology,</institution><institution>University of North Carolina at Chapel Hill,</institution></institution-wrap>Chapel Hill, North Carolina USA</nlm:aff><wicri:noCountry code="subfield">North Carolina USA</wicri:noCountry></affiliation></author><author><name sortKey="Randell, Scott H" sort="Randell, Scott H" uniqKey="Randell S" first="Scott H" last="Randell">Scott H. Randell</name><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.10698.36</institution-id><institution-id institution-id-type="ISNI">0000000122483208</institution-id><institution>Department of Cell Biology and Physiology,</institution><institution>University of North Carolina at Chapel Hill,</institution></institution-wrap>Chapel Hill, North Carolina USA</nlm:aff><wicri:noCountry code="subfield">North Carolina USA</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.10698.36</institution-id><institution-id institution-id-type="ISNI">0000000122483208</institution-id><institution>Cystic Fibrosis Center, Marsico Lung Institute, University of North Carolina at Chapel Hill,</institution></institution-wrap>Chapel Hill, North Carolina USA</nlm:aff><wicri:noCountry code="subfield">North Carolina USA</wicri:noCountry></affiliation></author><author><name sortKey="Lanzavecchia, Antonio" sort="Lanzavecchia, Antonio" uniqKey="Lanzavecchia A" first="Antonio" last="Lanzavecchia">Antonio Lanzavecchia</name><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="GRID">grid.5801.c</institution-id><institution-id institution-id-type="ISNI">0000 0001 2156 2780</institution-id><institution>Institute for Research in Biomedicine, Bellinzona Institute of Microbiology,</institution></institution-wrap>Zurich, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Zurich</wicri:regionArea></affiliation></author><author><name sortKey="Marasco, Wayne A" sort="Marasco, Wayne A" uniqKey="Marasco W" first="Wayne A" last="Marasco">Wayne A. Marasco</name><affiliation><nlm:aff id="Aff8">Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts USA</nlm:aff><wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="GRID">grid.38142.3c</institution-id><institution-id institution-id-type="ISNI">000000041936754X</institution-id><institution>Department of Medicine,</institution><institution>Harvard Medical School,</institution></institution-wrap>Boston, Massachusetts USA</nlm:aff><wicri:noCountry code="subfield">Massachusetts USA</wicri:noCountry></affiliation></author><author><name sortKey="Shi, Zhengli Li" sort="Shi, Zhengli Li" uniqKey="Shi Z" first="Zhengli-Li" last="Shi">Zhengli-Li Shi</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.439104.b</institution-id><institution-id institution-id-type="ISNI">0000 0004 1798 1925</institution-id><institution>Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences,</institution></institution-wrap>Wuhan, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Wuhan</wicri:regionArea></affiliation></author><author><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.10698.36</institution-id><institution-id institution-id-type="ISNI">0000000122483208</institution-id><institution>Department of Epidemiology,</institution><institution>University of North Carolina at Chapel Hill,</institution></institution-wrap>Chapel Hill, North Carolina USA</nlm:aff><wicri:noCountry code="subfield">North Carolina USA</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.10698.36</institution-id><institution-id institution-id-type="ISNI">0000000122483208</institution-id><institution>Department of Microbiology and Immunology,</institution><institution>University of North Carolina at Chapel Hill,</institution></institution-wrap>Chapel Hill, North Carolina USA</nlm:aff><wicri:noCountry code="subfield">North Carolina USA</wicri:noCountry></affiliation></author></analytic><series><title level="j">Nature Medicine</title><idno type="ISSN">1078-8956</idno><idno type="eISSN">1546-170X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Monoclonal (immunology)</term><term>Antibodies, Viral (immunology)</term><term>Cell Line</term><term>Chiroptera (virology)</term><term>Epidemics</term><term>Epithelial Cells (pathology)</term><term>Epithelial Cells (virology)</term><term>Female</term><term>Humans</term><term>Lung (virology)</term><term>Mice, Inbred BALB C</term><term>Neutralization Tests</term><term>Phylogeny</term><term>SARS Virus (immunology)</term><term>SARS Virus (pathogenicity)</term><term>SARS Virus (physiology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Virulence</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (immunologie)</term><term>Anticorps monoclonaux (immunologie)</term><term>Cellules épithéliales (anatomopathologie)</term><term>Cellules épithéliales (virologie)</term><term>Chiroptera (virologie)</term><term>Femelle</term><term>Humains</term><term>Lignée cellulaire</term><term>Phylogénie</term><term>Poumon (virologie)</term><term>Réplication virale</term><term>Souris de lignée BALB C</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Tests de neutralisation</term><term>Virulence</term><term>Virus du SRAS (immunologie)</term><term>Virus du SRAS (pathogénicité)</term><term>Virus du SRAS (physiologie)</term><term>Épidémies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules épithéliales</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps monoclonaux</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Epithelial Cells</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules épithéliales</term><term>Chiroptera</term><term>Poumon</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chiroptera</term><term>Epithelial Cells</term><term>Lung</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Epidemics</term><term>Female</term><term>Humans</term><term>Mice, Inbred BALB C</term><term>Neutralization Tests</term><term>Phylogeny</term><term>Virulence</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Humains</term><term>Lignée cellulaire</term><term>Phylogénie</term><term>Réplication virale</term><term>Souris de lignée BALB C</term><term>Tests de neutralisation</term><term>Virulence</term><term>Épidémies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par2">Ralph Baric, Vineet Menachery and colleagues characterize a SARS-like coronavirus circulating in Chinese horseshoe bats to determine its potential to infect primary human airway epithelial cells, cause disease in mice and respond to available therapeutics.</p><sec><title>Supplementary information</title><p>The online version of this article (doi:10.1038/nm.3985) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ge, Xy" uniqKey="Ge X">XY Ge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yount, B" uniqKey="Yount B">B Yount</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Becker, Mm" uniqKey="Becker M">MM Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, B" uniqKey="He B">B He</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheahan, T" uniqKey="Sheahan T">T Sheahan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yoshikawa, T" uniqKey="Yoshikawa T">T Yoshikawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qiu, X" uniqKey="Qiu X">X Qiu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rockx, B" uniqKey="Rockx B">B Rockx</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spruth, M" uniqKey="Spruth M">M Spruth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bolles, M" uniqKey="Bolles M">M Bolles</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Deming, D" uniqKey="Deming D">D Deming</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Donaldson, Ef" uniqKey="Donaldson E">EF Donaldson</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Relman, Da" uniqKey="Relman D">DA Relman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Frieman, M" uniqKey="Frieman M">M Frieman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, W" uniqKey="Ren W">W Ren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fulcher, Ml" uniqKey="Fulcher M">ML Fulcher</name></author><author><name sortKey="Gabriel, S" uniqKey="Gabriel S">S Gabriel</name></author><author><name sortKey="Burns, Ka" uniqKey="Burns K">KA Burns</name></author><author><name sortKey="Yankaskas, Jr" uniqKey="Yankaskas J">JR Yankaskas</name></author><author><name sortKey="Randell, Sh" uniqKey="Randell S">SH Randell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roberts, Anjeanette" uniqKey="Roberts A">Anjeanette Roberts</name></author><author><name sortKey="Deming, Damon" uniqKey="Deming D">Damon Deming</name></author><author><name sortKey="Paddock, Christopher D" uniqKey="Paddock C">Christopher D. Paddock</name></author><author><name sortKey="Cheng, Aaron" uniqKey="Cheng A">Aaron Cheng</name></author><author><name sortKey="Yount, Boyd" uniqKey="Yount B">Boyd Yount</name></author><author><name sortKey="Vogel, Leatrice" uniqKey="Vogel L">Leatrice Vogel</name></author><author><name sortKey="Herman, Brian D" uniqKey="Herman B">Brian D. Herman</name></author><author><name sortKey="Sheahan, Tim" uniqKey="Sheahan T">Tim Sheahan</name></author><author><name sortKey="Heise, Mark" uniqKey="Heise M">Mark Heise</name></author><author><name sortKey="Genrich, Gillian L" uniqKey="Genrich G">Gillian L. Genrich</name></author><author><name sortKey="Zaki, Sherif R" uniqKey="Zaki S">Sherif R. Zaki</name></author><author><name sortKey="Baric, Ralph" uniqKey="Baric R">Ralph Baric</name></author><author><name sortKey="Subbarao, Kanta" uniqKey="Subbarao K">Kanta Subbarao</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li><li>Suisse</li></country></list><tree><noCountry><name sortKey="Agnihothram, Sudhakar" sort="Agnihothram, Sudhakar" uniqKey="Agnihothram S" first="Sudhakar" last="Agnihothram">Sudhakar Agnihothram</name><name sortKey="Baric, Ralph S" sort="Baric, Ralph S" uniqKey="Baric R" first="Ralph S" last="Baric">Ralph S. Baric</name><name sortKey="Debbink, Kari" sort="Debbink, Kari" uniqKey="Debbink K" first="Kari" last="Debbink">Kari Debbink</name><name sortKey="Donaldson, Eric F" sort="Donaldson, Eric F" uniqKey="Donaldson E" first="Eric F" last="Donaldson">Eric F. Donaldson</name><name sortKey="Graham, Rachel L" sort="Graham, Rachel L" uniqKey="Graham R" first="Rachel L" last="Graham">Rachel L. Graham</name><name sortKey="Gralinski, Lisa E" sort="Gralinski, Lisa E" uniqKey="Gralinski L" first="Lisa E" last="Gralinski">Lisa E. Gralinski</name><name sortKey="Marasco, Wayne A" sort="Marasco, Wayne A" uniqKey="Marasco W" first="Wayne A" last="Marasco">Wayne A. Marasco</name><name sortKey="Menachery, Vineet D" sort="Menachery, Vineet D" uniqKey="Menachery V" first="Vineet D" last="Menachery">Vineet D. Menachery</name><name sortKey="Plante, Jessica A" sort="Plante, Jessica A" uniqKey="Plante J" first="Jessica A" last="Plante">Jessica A. Plante</name><name sortKey="Randell, Scott H" sort="Randell, Scott H" uniqKey="Randell S" first="Scott H" last="Randell">Scott H. Randell</name><name sortKey="Scobey, Trevor" sort="Scobey, Trevor" uniqKey="Scobey T" first="Trevor" last="Scobey">Trevor Scobey</name><name sortKey="Yount, Boyd L" sort="Yount, Boyd L" uniqKey="Yount B" first="Boyd L" last="Yount">Boyd L. Yount</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Ge, Xing Yi" sort="Ge, Xing Yi" uniqKey="Ge X" first="Xing-Yi" last="Ge">Xing-Yi Ge</name></noRegion><name sortKey="Shi, Zhengli Li" sort="Shi, Zhengli Li" uniqKey="Shi Z" first="Zhengli-Li" last="Shi">Zhengli-Li Shi</name></country><country name="Suisse"><noRegion><name sortKey="Lanzavecchia, Antonio" sort="Lanzavecchia, Antonio" uniqKey="Lanzavecchia A" first="Antonio" last="Lanzavecchia">Antonio Lanzavecchia</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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